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Centre for Stem Cell Biology - University of Sheffield

Professor Peter Andrews

As co-director of the Centre for Stem Cell Biology at the University of Sheffield, I will act in an advisory capacity in respect of the work to be undertaken.

My research focuses on the biology of pluripotent human stem cells, with particular emphasis on human embryonic stem cells and the mechanisms governing their self renewal and adaptation to culture. 

Among my current activities, I co-ordinate the International Stem Cell Initiative - a large scale collaborative project to determine standard markers and culture conditions for human embryonic stem cells. I also co-ordinate the multi-million pound EU Framework 6 programme, ESTools, in which twenty partner organisations are developing a suite of valuable resources that will expedite research and development within the field.

Key achievements

Derivation of pluripotent human embryonal carcinoma cell lines and development of their use as an in vitro model of human development

Production and characterisation of monoclonal antibodies recognising cell surface markers on human embryonal carcinoma cells, embryonic stem cells and their derivatives

Chairman of dept Biomedical Sciences University of Sheffield

Arthur Jackson Chair of Biomedical Sciences.

Co-director of Sheffield Centre for Stem Cell Biology

Member of UK Stem Cell Bank User Liaison and UK Stem Cell Bank management Committee’s

Co-ordinator of the International Human Embryonic Stem Cell Characterisation Group for the International Stem Cell Forum

Co-ordinator of ESTools programme

Member of the MRC Cell and Molecular Biology Board.

Key publications

  • Baker, D.E.C., Harrison, N.J., Maltby, E., Smith, K., Moore, H.D., Shaw, P.J., Heath, P.R., Holden, H., Andrews, P.W.  (2007)  Adaptation to culture of human embryonic stem cells and oncogenesis in vivo.  Nature Biotechnology 25: 207 – 215.
  • Draper J.S. Smith, K., Gokhale, P.J., Moore, H.D., Maltby, E., Johnson, J., Meisner, L., Zwaka, T.P.,  Thomson, J.A., Andrews P.W. (2004)  Karyotypic evolution of human Embryonic Stem (ES) cells in culture: recurrent gain of chromosomes 17 (17q) and 12.  Nat. Biotech.  22: 53-54 (e-pub. 2003 Dec 07)
  • Matin M.M, Walsh, J.R, Gokhale, P.J, Draper, J.S, Bahrami, A, Morton, I, Moore, H.D, Andrews, P.W. (2004)  RNA interference mediated knock-down of Oct4 expression induces differentiation of human EC and ES cells.  Stem Cells, 22:659 -668.
  • Simeone A., Acampora D., Arcioni L., Andrews P.W., Boncinelli E. and Mavilio F. (1990).  Sequential activation of human HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells.  Nature 346: 763-766.
  • Andrews P.W. (1984)  Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro.  Dev. Biol. 103: 285-293.